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Chapter 7. Toxicokinetics

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Regarding the two-compartment model of classic toxicokinetics, which of the following is true?

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a. There is rapid equilibration of chemical between central and peripheral compartments.

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b. The logarithm of plasma concentration versus time data yields a linear relationship.

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c. There is more than one dispositional phase.

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d. It is assumed that the concentration of a chemical is the same throughout the body.

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e. It is ineffective in determining effective doses in toxicity studies.

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When calculating the fraction of a dose remaining in the body over time, which of the following factors need not be taken into consideration?

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a. half-life.

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b. initial concentration.

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c. time.

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d. present concentration.

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e. elimination rate constant.

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All of the following statements regarding apparent volume of distribution (Vd) are true EXCEPT:

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a. Vd relates the total amount of chemical in the body to the concentration of chemical in the plasma.

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b. Vd is the apparent space into which an amount of chemical is distributed in the body to result in a given plasma concentration.

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c. A chemical that usually remains in the plasma has a low Vd.

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d. Vd will be low for a chemical with high affinity for tissues.

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e. Vd can be used to estimate the amount of chemical in the body if the plasma concentration is known.

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Chemical clearance:

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a. is independent of Vd.

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b. is unaffected by kidney failure.

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c. is indirectly proportional to Vd.

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d. is performed by multiple organs.

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e. is not appreciable in the GI tract.

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A chemical with which of the following half-lives (T1/2) will remain in the body for the longest period of time when given equal dosage of each?

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a. T1/2 = 30 min.

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b. T1/2 = 1 day.

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c. T1/2 = 7 h.

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d. T1/2 = 120 s.

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