Skip to Main Content

++

Chapter 8. Chemical Carcinogenesis

++
++
++

There is evidence that certain dietary components are carcinogenic. Which of the following is NOT tabbed as a dietary carcinogen?

+
+
++

a. excessive caloric intake.

+
++

b. excessive alcohol consumption.

+
++

c. aflatoxin B1 (a food contaminant).

+
++

d. insufficient caloric intake.

+
++

e. nitrites (found in some lunchmeats).

++
++
++

Which of the following statements regarding mechanisms of chemical carcinogenesis is FALSE?

+
+
++

a. Procarcinogens require metabolism in order to exert their carcinogenic effect.

+
++

b. Free radicals are highly reactive molecules that have a single, unpaired electron.

+
++

c. DNA adducts interfere with the DNA replication machinery.

+
++

d. Mutations in the DNA and failure to repair those mutations can be highly carcinogenic.

+
++

e. Biological reduction of molecular oxygen is the only way free radicals can be formed.

++
++
++

In addition to being necessary for transcription to occur, which of the following transcription factors also plays a crucial role in nucleotide excision repair?

+
+
++

a. TFIIA.

+
++

b. TFIIB.

+
++

c. TFIID.

+
++

d. TFIIF.

+
++

e. TFIIH.

++
++
++

Which of the following statements regarding DNA repair is true?

+
+
++

a. Base excision repair requires the removal of a longer piece of DNA in comparison with nucleotide excision repair.

+
++

b. The repair of double-stranded DNA breaks is more prone to error than is base excision repair.

+
++

c. Dimerization of pyrimidines is repaired via base excision repair.

+
++

d. Mismatch repair can only recognize normal nucleotides that are paired with a noncomplementary nucleotide.

+
++

e. Nucleotide excision and base excision are tolerance mechanisms used to respond to DNA damage.

++
++
++

Which of the following statements is a characteristic of the initiation stage of carcinogenesis?

+
+
++

a. Initiation is reversible in viable cells.

+
++

b. The dose–response exhibits an easily measurable threshold.

+
++

c. Cell division is required for the fixation of the process.

+
++

d. All initiated cells survive over the lifespan of the organism.

+
++

e. Spontaneous initiation of cells is a rare occurrence.

++
++
++

Tumor suppressor genes are ...

Pop-up div Successfully Displayed

This div only appears when the trigger link is hovered over. Otherwise it is hidden from view.