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Chapter 13. Toxic Responses of the Liver

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The impairment of hepatic function can have numerous negative consequences. Which of the following is likely NOT caused by impaired hepatic function?

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a. jaundice.

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b. hypercholesterolemia.

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c. hyperammonemia.

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d. hyperglycemia.

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e. hypoalbuminemia.

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All of the following statements regarding the liver are true EXCEPT:

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a. The major role of the liver is to maintain metabolic homeostasis of the body.

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b. The liver encounters ingested nutrients before the heart does.

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c. Hepatic triads contain a branch of the hepatic portal vein, a branch of the hepatic artery, and a bile ductule.

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d. The liver manufactures and stores bile.

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e. The large fenestrae of hepatic sinusoids facilitate exchange of materials between the sinusoid and the hepatocyte.

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Activation of which of the following cell types can result in increased secretion of collagen scar tissue, leading to cirrhosis?

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a. hepatocyte.

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b. Ito cell.

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c. Kupffer cell.

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d. endothelial cell.

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e. β-cell.

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Wilson’s disease is a rare genetic disorder characterized by the failure to export which of the following metals into bile?

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a. iron.

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b. zinc.

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c. silver.

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d. lead.

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e. copper.

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Which of the following is NOT characteristic of apoptosis?

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a. cell swelling.

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b. nuclear fragmentation.

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c. lack of inflammation.

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d. programmed death.

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e. chromatin condensation.

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A patient suffering from canalicular cholestasis would NOT be expected to exhibit which of the following?

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a. increased bile salt serum levels.

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b. jaundice.

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c. increased bile formation.

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d. dark brown urine.

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e. vitamin A deficiency.

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Which of the following statements regarding liver injury is FALSE?

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a. Large doses of acetaminophen have been shown to cause ...

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