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Chapter 19. Toxic Responses of the Skin

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Which of the following statements is FALSE regarding skin histology?

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a. Blood supply to the epidermis originates in the epidermal–dermal junction.

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b. Melanin is made and stored by melanocytes.

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c. The stratum corneum is made up of nonviable cells.

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d. It takes approximately 2 weeks for cells to be sloughed off from the stratum corneum.

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e. Stem cells in the basal layer replenish the keratinocytes of the layers of epidermis.

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Transdermal drug delivery does NOT:

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a. prevent drug exposure to low pH.

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b. avoid first-pass metabolism.

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c. provide steady infusion over an extended period of time.

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d. avoid large variation in drug plasma concentration.

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e. increase safety of drug delivery.

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Irritant and contact dermatitis are marked by all of the following characteristics EXCEPT:

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a. softness.

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b. erythema.

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c. flaking.

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d. induration.

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e. blistering.

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Nickel is a common cause of allergic contact dermatitis, which is which type of hypersensitivity reaction?

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a. type I.

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b. type II.

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c. type III.

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d. type IV.

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e. type V.

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All of the following statements regarding phototoxicology are true EXCEPT:

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a. Melanin is primarily responsible for the absorption of UV-B radiation.

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b. UV-A is the most effective at causing sunburn in humans.

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c. IL-1 release is responsible for systemic symptoms associated with sunburn.

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d. Melanin darkening is a common response to UV exposure.

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e. UV radiation exposure causes thickening of the stratum corneum.

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Photoallergies:

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a. represent a form of type III hypersensitivity reaction.

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b. can occur without exposure to UV radiation.

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c. are hapten-mediated

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d. cannot be tested for as contact dermatitis allergies can.

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e. often occur on first exposure.

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