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Goodman and Gilman's Manual of Pharmacology and Therapeutics, Second Edition, Copyright © 2014, 2008 by The McGraw-Hill Companies, Inc. All rights reserved. Printed in China. Except as permitted under the United States Copyright Act of 1976, no part of this publication may be reproduced or distributed in any form or by any means, or stored in a data base or retrieval system, without the prior written permission of the publisher.

1 2 3 4 5 6 7 8 9 0 CTP/CTP 18 17 16 15 14 13

ISBN 978-0-07-176917-4

MHID 0-07-176917-X

ISE ISBN 978-0-07-179288-2

ISE MHID 0-07-179288-0

This book was set in Times New Roman PS by Thomson Digital.

The editors were James F. Shanahan and Christie Naglieri.

The production supervisor was Richard Ruzycka.

The illustration manager was Armen Ovsepyan.

Project management was provided by Saloni Narang, Thomson Digital.

The designer was Janice Bielawa; the cover designer was Thomas De Pierro.

China Translation & Printing Services, Ltd. was printer and binder.

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