TY  - CHAP
M1  - Book, Section
TI  - SEVERE SEPSIS AND SEPTIC SHOCK
A1  - Munford, Robert S.
A2  - Kasper, Dennis L.
A2  - Fauci, Anthony S.
Y1  - 2017
N1  - 
T2  - Harrison's Infectious Diseases, 3e
AB  - (Table  19-1)  Animals  mount  both  local  and  systemic  responses  to  microbes  that  traverse  their  epithelial  barriers  and  enter  underlying  tissues.  Fever  or  hypothermia,  leukocytosis  or  leukopenia,  tachypnea,  and  tachycardia  are  cardinal  signs  of  the  systemic  response.  To  date,  attempts  to  devise  precise  definitions  for  the  harmful  systemic  reaction  to  infection  (“sepsis”)  have  not  resulted  in  a  clinically  useful  level  of  specificity,  in  part  because  the  systemic  responses  to  infection,  trauma,  and  other  major  stresses  can  be  so  similar.  In  general,  when  an  infectious  etiology  is  proven  or  strongly  suspected  and  the  response  results  in  hypofunction  of  uninfected  organs,  the  term  sepsis  (or  severe  sepsis)  should  be  used.  Septic  shock  refers  to  sepsis  accompanied  by  hypotension  that  cannot  be  corrected  by  the  infusion  of  fluids.  
SN  - 
PB  - McGraw-Hill Education
CY  - New York, NY
Y2  - 2024/04/19
UR  - accessbiomedicalscience.mhmedical.com/content.aspx?aid=1141405587
ER  -