TY  - CHAP
M1  - Book, Section
TI  - Principles of Toxicology
A1  - Eaton, David L.
A1  - Gilbert, Steven G.
Y1  - 2012
N1  - 
T2  - Casarett and Doull's Toxicology: The Basic Science of Poisons, 8e
AB  - Introduction  to  ToxicologyDifferent  Areas  of  ToxicologyToxicology  and  SocietyGeneral  Characteristics  of  the  Toxic  ResponseClassification  of  Toxic  AgentsSpectrum  of  Undesired  EffectsAllergic  ReactionsIdiosyncratic  ReactionsImmediate  versus  Delayed  ToxicityReversible  versus  Irreversible  Toxic  EffectsLocal  versus  Systemic  ToxicityInteraction  of  ChemicalsToleranceCharacteristics  of  ExposureRoute  and  Site  of  ExposureDuration  and  Frequency  of  ExposureDose–Response  RelationshipIndividual,  or  Graded,  Dose–Response  RelationshipsQuantal  Dose–Response  RelationshipsShape  of  the  Dose–Response  CurveEssential  NutrientsHormesisThresholdNonmonotonic  Dose–Response  CurvesAssumptions  in  Deriving  the  Dose–Response  RelationshipEvaluating  the  Dose–Response  RelationshipComparison  of  Dose  ResponsesTherapeutic  IndexMargins  of  Safety  and  ExposurePotency  versus  EfficacyVariation  in  Toxic  ResponsesSelective  ToxicitySpecies  DifferencesIndividual  Differences  in  ResponseDescriptive  Animal  Toxicity  TestsAcute  Toxicity  TestingSkin  and  Eye  IrritationsSensitizationSubacute  (Repeated-Dose  Study)SubchronicChronicDevelopmental  and  Reproductive  ToxicityMutagenicityOncogenicity  BioassaysNeurotoxicity  AssessmentImmunotoxicity  AssessmentOther  Descriptive  Toxicity  TestsToxicogenomicsGenomicsEpigenetics/EpigenomicsTranscriptomicsProteomicsMetabonomics/MetabolomicsBioinformaticsChallenges  in  Using  “Omics”  Technologies  for  Predictive  Toxicology  and  Risk  Assessment  
SN  - 
PB  - McGraw-Hill Education
CY  - New York, NY
Y2  - 2024/04/19
UR  - accessbiomedicalscience.mhmedical.com/content.aspx?aid=1100084201
ER  -