TY  - CHAP
M1  - Book, Section
TI  - Toxic Responses of the Kidney
A1  - Schnellmann, Rick G.
A2  - Klaassen, Curtis D.
A2  - Watkins III, John B.
PY  - 2015
T2  - Casarett & Doull’s Essentials of Toxicology, 3e
AB  - The  kidney  contributes  to  total  body  homeostasis  via  its  role  in  the  excretion  of  metabolic  wastes,  the  synthesis  and  release  of  renin  and  erythropoietin,  and  the  regulation  of  extracellular  fluid  volume,  electrolyte  composition,  and  acid–base  balance.Xenobiotics  in  the  systemic  circulation  will  be  delivered  to  the  kidney  in  relatively  high  amounts.The  processes  that  concentrate  urine  also  serve  to  concentrate  potential  toxicants  in  the  tubular  fluid.Renal  transport,  accumulation,  and  biotransformation  of  xenobiotics  contribute  to  the  susceptibility  of  the  kidney  to  toxic  injury.Numerous  nephrotoxicants  cause  mitochondrial  dysfunction  via  compromised  respiration  and  ATP  production,  or  some  other  cellular  process,  leading  to  either  apoptosis  or  necrosis.  
SN  - 
PB  - McGraw-Hill Education
CY  - New York, NY
Y2  - 2024/04/19
UR  - accessbiomedicalscience.mhmedical.com/content.aspx?aid=1113950318
ER  -