RT Book, Section
A1 Hilal-Dandan, Randa
A1 Brunton, Laurence L.
SR Print(0)
ID 1127552135
T1 Estrogens and Progestins
T2 Goodman and Gilman's Manual of Pharmacology and Therapeutics, 2e
YR 2016
FD 2016
PB McGraw-Hill Education
PP New York, NY
SN 9780071769174
LK accessbiomedicalscience.mhmedical.com/content.aspx?aid=1127552135
RD 2024/04/19
AB Estrogens  and  progestins  are  hormones  that  produce  myriad  physiological  actions.  In  women,  these  include  developmental  effects,  neuroendocrine  actions  involved  in  the  control  of  ovulation,  the  cyclical  preparation  of  the  reproductive  tract  for  fertilization  and  implantation,  and  major  actions  on  mineral,  carbohydrate,  protein,  and  lipid  metabolism.  Estrogens  also  have  important  actions  in  males,  including  effects  on  bone,  spermatogenesis,  and  behavior.  The  most  common  uses  of  these  agents  are  menopausal  hormone  therapy  and  contraception  in  women,  but  the  specific  compounds  and  dosages  used  in  these  2  settings  differ  substantially.  Anti-estrogens  are  used  in  the  treatment  of  hormone-responsive  breast  cancer  and  infertility.  Selective  estrogen  receptor  modulators  (SERMs)  that  display  tissue-selective  agonist  or  antagonist  activities  are  useful  to  prevent  breast  cancer  and  osteoporosis.  The  main  use  of  antiprogestins  has  been  for  medical  abortion.