RT Book, Section
A1 Munshi, Nikhil C.
A1 Longo, Dan L.
A1 Anderson, Kenneth C.
A2 Longo, Dan L.
SR Print(0)
ID 1135227554
T1 Plasma Cell Disorders
T2 Harrison's Hematology and Oncology, 3e
YR 2016
FD 2016
PB McGraw-Hill Education
PP New York, NY
SN 9781259835834
LK accessbiomedicalscience.mhmedical.com/content.aspx?aid=1135227554
RD 2024/04/24
AB The  plasma  cell  disorders  are  monoclonal  neoplasms  related  to  each  other  by  virtue  of  their  development  from  common  progenitors  in  the  B-lymphocyte  lineage.  Multiple  myeloma,  Waldenström’s  macroglobulinemia,  primary  amyloidosis  (Chap.  19),  and  the  heavy  chain  diseases  comprise  this  group  and  may  be  designated  by  a  variety  of  synonyms  such  as  monoclonal  gammopathies,  paraproteinemias,  plasma  cell  dyscrasias,  and  dysproteinemias.  Mature  B  lymphocytes  destined  to  produce  IgG  bear  surface  immunoglobulin  molecules  of  both  M  and  G  heavy  chain  isotypes  with  both  isotypes  having  identical  idiotypes  (variable  regions).  Under  normal  circumstances,  maturation  to  antibody-secreting  plasma  cells  and  their  proliferation  is  stimulated  by  exposure  to  the  antigen  for  which  the  surface  immunoglobulin  is  specific;  however,  in  the  plasma  cell  disorders,  the  control  over  this  process  is  lost.  The  clinical  manifestations  of  all  the  plasma  cell  disorders  relate  to  the  expansion  of  the  neoplastic  cells,  to  the  secretion  of  cell  products  (immunoglobulin  molecules  or  subunits,  lymphokines),  and  to  some  extent  to  the  host’s  response  to  the  tumor.  Normal  development  of  B  lymphocytes  is  depicted  in  Fig.  16-2.