RT Book, Section A1 Goldhaber, Samuel Z. A2 Longo, Dan L. SR Print(0) ID 1135227883 T1 Deep Venous Thrombosis and Pulmonary Thromboembolism T2 Harrison's Hematology and Oncology, 3e YR 2016 FD 2016 PB McGraw-Hill Education PP New York, NY SN 9781259835834 LK accessbiomedicalscience.mhmedical.com/content.aspx?aid=1135227883 RD 2024/04/19 AB Venous thromboembolism (VTE) encompasses deep venous thrombosis (DVT) and pulmonary embolism (PE) and causes cardiovascular death and disability. In the United States, the Surgeon General estimates there are 100,000 to 180,000 deaths annually from PE and has declared that PE is the most common preventable cause of death among hospitalized patients. Survivors may succumb to the disabilities of chronic thromboembolic pulmonary hypertension or postthrombotic syndrome. Chronic thromboembolic pulmonary hypertension causes breathlessness, especially with exertion. Postthrombotic syndrome (also known as chronic venous insufficiency) damages the venous valves of the leg and causes ankle or calf swelling and leg aching, especially after prolonged standing. In its most severe form, postthrombotic syndrome causes skin ulceration (Fig. 23-1).