RT Book, Section
A1 Powers, Alvin C.
A2 Jameson, J. Larry
SR Print(0)
ID 1141275568
T1 Diabetes Mellitus: Diagnosis, Classification, and Pathophysiology
T2 Harrison's Endocrinology, 4e
YR 2017
FD 2017
PB McGraw-Hill Education
PP New York, NY
SN 9781259835728
LK accessbiomedicalscience.mhmedical.com/content.aspx?aid=1141275568
RD 2024/04/19
AB Diabetes  mellitus  (DM)  refers  to  a  group  of  common  metabolic  disorders  that  share  the  phenotype  of  hyperglycemia.  Several  distinct  types  of  DM  are  caused  by  a  complex  interaction  of  genetics  and  environmental  factors.  Depending  on  the  etiology  of  the  DM,  factors  contributing  to  hyperglycemia  include  reduced  insulin  secretion,  decreased  glucose  utilization,  and  increased  glucose  production.  The  metabolic  dysregulation  associated  with  DM  causes  secondary  pathophysiologic  changes  in  multiple  organ  systems  that  impose  a  tremendous  burden  on  the  individual  with  diabetes  and  on  the  health  care  system.  In  the  United  States,  DM  is  the  leading  cause  of  end-stage  renal  disease  (ESRD),  nontraumatic  lower  extremity  amputations,  and  adult  blindness.  It  also  predisposes  to  cardiovascular  diseases.  With  an  increasing  incidence  worldwide,  DM  will  be  likely  a  leading  cause  of  morbidity  and  mortality  in  the  future.