RT Book, Section A1 Powers, Alvin C. A2 Jameson, J. Larry SR Print(0) ID 1141275806 T1 Diabetes Mellitus: Complications T2 Harrison's Endocrinology, 4e YR 2017 FD 2017 PB McGraw-Hill Education PP New York, NY SN 9781259835728 LK accessbiomedicalscience.mhmedical.com/content.aspx?aid=1141275806 RD 2024/04/23 AB Diabetes-related complications affect many organ systems and are responsible for the majority of morbidity and mortality associated with the disease. Strikingly, in the United States, diabetes is the leading cause of new blindness in adults, renal failure, and nontraumatic lower extremity amputation. Diabetes-related complications usually do not appear until the second decade of hyperglycemia. Because type 2 ­diabetes mellitus (DM) often has a long asymptomatic period of hyperglycemia before diagnosis, many individuals with type 2 DM have complications at the time of diagnosis. Fortunately, many of the diabetes-related complications can be prevented or delayed with early detection, aggressive glycemic control, and efforts to minimize the risks of complications.