RT Book, Section
A1 Rader, Daniel J.
A1 Hobbs, Helen H.
A2 Jameson, J. Larry
SR Print(0)
ID 1141276041
T1 Disorders of Lipoprotein Metabolism
T2 Harrison's Endocrinology, 4e
YR 2017
FD 2017
PB McGraw-Hill Education
PP New York, NY
SN 9781259835728
LK accessbiomedicalscience.mhmedical.com/content.aspx?aid=1141276041
RD 2024/04/24
AB Lipoproteins  are  complexes  of  lipids  and  proteins  that  are  essential  for  transport  of  cholesterol,  triglycerides,  and  fat-soluble  vitamins.  Previously,  lipoprotein  disorders  were  the  purview  of  specialized  lipidologists,  but  the  demonstration  that  lipid-lowering  therapy  significantly  reduces  the  clinical  complications  of  atherosclerotic  cardiovascular  disease  (ASCVD)  has  brought  the  diagnosis  and  treatment  of  these  disorders  into  the  domain  of  the  internist.  The  number  of  individuals  who  are  candidates  for  lipid-lowering  therapy  continues  to  increase.  Therefore,  the  appropriate  diagnosis  and  management  of  lipoprotein  disorders  is  of  critical  importance  in  the  practice  of  medicine.  This  chapter  reviews  normal  lipoprotein  physiology,  the  pathophysiology  of  disorders  of  lipoprotein  metabolism,  the  effects  of  diet  and  other  environmental  factors  that  influence  lipoprotein  metabolism,  and  the  practical  approaches  to  the  diagnosis  and  management  of  lipoprotein  disorders.