RT Book, Section A1 Karchmer, Adolf W. A2 Kasper, Dennis L. A2 Fauci, Anthony S. SR Print(0) ID 1141405951 T1 INFECTIVE ENDOCARDITIS T2 Harrison's Infectious Diseases, 3e YR 2017 FD 2017 PB McGraw-Hill Education PP New York, NY SN 9781259835971 LK accessbiomedicalscience.mhmedical.com/content.aspx?aid=1141405951 RD 2024/04/24 AB The prototypic lesion of infective endocarditis, the vegetation(Fig. 24-1), is a mass of platelets, fibrin, microcolonies of microorganisms, and scant inflammatory cells. Infection most commonly involves heart valves but may also occur on the low-pressure side of a ventricular septal defect, on mural endocardium damaged by aberrant jets of blood or foreign bodies, or on intracardiac devices themselves. The analogous process involving arteriovenous shunts, arterio-arterial shunts (patent ductus arteriosus), or a coarctation of the aorta is called infective endarteritis.