RT Book, Section
A1 Baden, Lindsey R.
A1 Dolin, Raphael
A2 Kasper, Dennis L.
A2 Fauci, Anthony S.
SR Print(0)
ID 1141410603
T1 ANTIVIRAL CHEMOTHERAPY, EXCLUDING ANTIRETROVIRAL DRUGS
T2 Harrison's Infectious Diseases, 3e
YR 2017
FD 2017
PB McGraw-Hill Education
PP New York, NY
SN 9781259835971
LK accessbiomedicalscience.mhmedical.com/content.aspx?aid=1141410603
RD 2024/04/23
AB The  field  of  antiviral  therapy—both  the  number  of  antiviral  drugs  and  our  understanding  of  their  optimal  use—historically  has  lagged  behind  that  of  antibacterial  treatment,  but  significant  progress  has  been  made  in  recent  years  on  new  drugs  for  several  viral  infections.  The  development  of  antiviral  drugs  poses  several  challenges.  Viruses  replicate  intracellularly  and  often  use  host  cell  enzymes,  macromolecules,  and  organelles  for  synthesis  of  viral  particles.  Therefore,  useful  antiviral  compounds  must  discriminate  between  host  and  viral  functions  with  a  high  degree  of  specificity;  agents  without  such  selectivity  are  likely  to  be  too  toxic  for  clinical  use.