RT Book, Section
A1 Zanger, Ulrich M.
A2 Murray, Michael F.
A2 Babyatsky, Mark W.
A2 Giovanni, Monica A.
A2 Alkuraya, Fowzan S.
A2 Stewart, Douglas R.
SR Print(0)
ID 1102698429
T1 Common Cytochrome P450 Polymorphisms and Pharmacogenetics
T2 Clinical Genomics: Practical Applications in Adult Patient Care
YR 2014
FD 2014
PB McGraw-Hill Education
PP New York, NY
SN 9780071622448
LK accessbiomedicalscience.mhmedical.com/content.aspx?aid=1102698429
RD 2024/04/20
AB Disease  summary:In  this  chapter,  relatively  common  (>1%  frequency)  and  ethically  diverse  genetic  polymorphisms  of  drug-metabolizing  cytochrome  P450s  (CYPs)  will  be  reviewed.  In  general,  these  variantsAffect  pharmacokinetics  and  response  to  drugs  which  are  substrates  of  these  enzymesAre  not  usually  associated  with  drug-independent  clinical  phenotypesHave  pharmacokinetic  phenotypes  categorized  as  poor,  intermediate,  normal  (extensive),  and  ultrarapid  metabolizer  (UM)Have  clinical  phenotypes  which  depend  on  the  particular  pharmacologic  situation  (drug,  prodrug,  therapeutic  index,  etc)