RT Book, Section
A1 Teekakirikul, Polakit
A1 Seidman, Christine E.
A1 Ho, Carolyn Y.
A2 Murray, Michael F.
A2 Babyatsky, Mark W.
A2 Giovanni, Monica A.
A2 Alkuraya, Fowzan S.
A2 Stewart, Douglas R.
SR Print(0)
ID 1102699478
T1 Hypertrophic Cardiomyopathy
T2 Clinical Genomics: Practical Applications in Adult Patient Care
YR 2014
FD 2014
PB McGraw-Hill Education
PP New York, NY
SN 9780071622448
LK accessbiomedicalscience.mhmedical.com/content.aspx?aid=1102699478
RD 2024/04/20
AB Disease  summary:Hypertrophic  cardiomyopathy  (HCM)  is  an  inherited  disorder  of  cardiac  muscle  characterized  by  left  ventricular  hypertrophy  (LVH)  in  the  absence  of  other  cardiovascular  or  systemic  conditions  (eg,  valvular  heart  diseases  or  long-standing  hypertension).The  histopathologic  hallmarks  include  myocyte  hypertrophy,  myocardial  disarray,  and  fibrosis.The  prevalence  of  HCM  is  1:500  in  the  general  population,  with  at  least  60%  caused  by  mutation  in  one  of  the  genes  encoding  different  components  of  the  sarcomere  protein  (see  Molecular  Genetics  section).