RT Book, Section
A1 Kent, Brian D.
A1 Ryan, Silke
A1 McNicholas, Walter T.
A2 Murray, Michael F.
A2 Babyatsky, Mark W.
A2 Giovanni, Monica A.
A2 Alkuraya, Fowzan S.
A2 Stewart, Douglas R.
SR Print(0)
ID 1102704715
T1 Obstructive Sleep Apnea Syndrome
T2 Clinical Genomics: Practical Applications in Adult Patient Care
YR 2014
FD 2014
PB McGraw-Hill Education
PP New York, NY
SN 9780071622448
LK accessbiomedicalscience.mhmedical.com/content.aspx?aid=1102704715
RD 2024/04/19
AB Disease  summary:Obstructive  sleep  apnea  syndrome  (OSAS)  is  a  highly  prevalent,  but  underdiagnosed  disorder.  Recurrent  collapse  of  the  upper  airway  during  sleep  causes  repetitive  episodes  of  intermittent  hypoxia,  and  recurrent  arousals  from  sleep,  leading  to  daytime  sleepiness,  poor  quality  of  life,  and  increased  risk  of  road  traffic  accidents,  cardiovascular  morbidity  and  mortality,  and  metabolic  dysfunction.Hereditary  basis:OSAS  is  approximately  twice  as  common  in  males.  Up  to  40%  of  the  variability  in  sleep  breathing  can  be  accounted  for  by  heritable  factors.  However,  a  discrete  genetic  basis  is  unlikely  in  the  majority  of  cases.Environmental  factors:Obesity  is  the  major  reversible  risk  factor  for  the  development  of  OSAS.  Factors  such  as  alcohol  use  and  sedative  medications  may  contribute  to  disease  severity.Differential  diagnosis:Simple  snoring,  obesity  hypoventilation  syndrome,  periodic  limb  movements  of  sleep,  narcolepsy,  shift  work  sleep  disorder,  congenital  central  hypoventilation  syndrome  (Ondine’s  curse).