119: Obstructive Sleep Apnea Syndrome

Key Points

• Disease summary:

  • Obstructive sleep apnea syndrome (OSAS) is a highly prevalent, but underdiagnosed disorder. Recurrent collapse of the upper airway during sleep causes repetitive episodes of intermittent hypoxia, and recurrent arousals from sleep, leading to daytime sleepiness, poor quality of life, and increased risk of road traffic accidents, cardiovascular morbidity and mortality, and metabolic dysfunction.

• Hereditary basis:

  • OSAS is approximately twice as common in males. Up to 40% of the variability in sleep breathing can be accounted for by heritable factors. However, a discrete genetic basis is unlikely in the majority of cases.

• Environmental factors:

  • Obesity is the major reversible risk factor for the development of OSAS. Factors such as alcohol use and sedative medications may contribute to disease severity.

• Differential diagnosis:

  • Simple snoring, obesity hypoventilation syndrome, periodic limb movements of sleep, narcolepsy, shift work sleep disorder, congenital central hypoventilation syndrome (Ondine’s curse).

Diagnostic Criteria and Clinical Characteristics

Diagnostic Criteria

A diagnosis of OSAS is based on the finding of significant respiratory disturbance due to collapse of the upper airway during sleep in the setting of compatible daytime symptomatology. The gold standard for diagnosis of OSAS is the performance of inpatient nocturnal polysomnography (PSG), which provides detailed information on respiration, sleep staging and quality, and a range of other variables including heart rate and rhythm. Sleep-disordered breathing is defined as an apnea-hypopnea index (AHI) of greater than five events per hour as measured by PSG, and can be further classified as mild (AHI 5-15 events per hour), moderate (AHI 15-30 events per hour), or severe (AHI >30 events per hour). Unfortunately, PSG is both resource intensive and time consuming for the patient, and a growing research interest lies in the development and validation of technologies facilitating the ambulatory investigation of subjects with suspected OSAS, but the utility of these methods requires confirmation in large-scale clinical outcome studies. A proposed diagnostic algorithm is presented in Fig. 119-1.

Clinical Characteristics

OSAS is a highly prevalent, but underdiagnosed disorder, affecting at least 4% of adult men and 2% of adult women in developed countries. OSAS is intimately and intrinsically linked with obesity, and its prevalence is likely to be increasing as the worldwide obesity epidemic develops. Patients may experience a wide variety of symptoms, ranging from snoring, nocturia, and witnessed apnea during sleep to impaired concentration, depression, and decreased libido. Excessive daytime sleepiness and fatigue are present in approximately 70% of cases. Untreated OSAS leads to reduced quality of life, impaired functional status, and reduced cognitive function. It is significantly associated with the risk of depressive illness, and markedly increases the risk of road traffic accidents.

However, the principal long-term adverse consequence of OSAS ...