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Goodman and Gilman's: The Pharmacological Basis of Therapeutics, Twelfth Edition Copyright © 2011, 2006, 2001, 1996, 1990, 1985, 1980, 1975, 1970, 1965, 1955, 1941 by The McGraw-Hill Companies, Inc. All rights reserved. Printed in China. Except as permitted under the United States Copyright Act of 1976, no part of this publication may be reproduced or distributed in any form or by any means, or stored in a database or retrieval system, without the prior written permission of the publisher.

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ISBN 978-0-07-162442-8

MHID 0-07-162442-2

Book ISBN 978-0-07-175352-4 Book MHID 0-07-175352-4

DVD ISBN 978-0-07-175306-7 DVD MHID 0-07-175306-0

Set ISBN 978-0-07-162442-8 Set MHID 0-07-162442-2

This book was set in Times by Glyph International.

The editors were James F. Shanahan and Christie Naglieri.

The production manager was Sherri Souffrance.

Project management was provided by Rajni Pisharody, Glyph International.

The illustration manager was Armen Ovsepyan.

The designer was Janice Bielawa.

The cover art director was Anthony Landi; the cover designer was Thomas De Pierro.

The indexer was Coughlin Indexing Services.

China Translation & Printing Services, Ltd., was printer and binder.

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