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This volume has been designed primarily as a textbook for, or adjunct to, courses in toxicology. However, it should also be of interest to those not directly involved in toxicologic education. For example, the research scientist in toxicology will find sections containing current reports on the status of circumscribed areas of special interest. Those concerned with community health, agriculture, food technology, pharmacy, veterinary medicine, and related disciplines will discover the contents to be most useful as a source of concepts and modes of thought that are applicable to other types of investigative and applied sciences. For those further removed from the field of toxicology or for those who have not entered a specific field of endeavor, this book attempts to present a selectively representative view of the many facets of the subject.

Toxicology: The Basic Science of Poisons has been organized to facilitate its use by these different types of users. The first section (Unit I) describes the elements of method and approach that identify toxicology. It includes those principles most frequently invoked in a full understanding of toxicologic events, such as dose— response, and is primarily mechanistically oriented. Mechanisms are also stressed in the subsequent sections of the book, particularly when these are well identified and extend across classic forms of chemicals and systems. However, the major focus in the second section (Unit II) is on the systemic site of action of toxins. The intent therein is to provide answers to two questions: What kinds of injury are produced in specific organs or systems by toxic agents? What are the agents that produce these effects? A more conventional approach to toxicology has been utilized in the third section (Unit III), in which the toxic agents are grouped by chemical or use characteristics. In the final section (Unit IV) an attempt has been made to illustrate the ramifications of toxicology into all areas of the health sciences and even beyond. This unit is intended to provide perspective for the nontoxicologist in the application of the results of toxicologic studies and a better understanding of the activities of those engaged in the various aspects of the discipline of toxicology.

It will be obvious to the reader that the contents of this book represent a compromise between the basic, fundamental, mechanistic approach to toxicology and the desire to give a view of the broad horizons presented by the subject. While it is certain that the editors’ selectivity might have been more severe, it is equally certain that it could have been less so, and we hope that the balance struck will prove to be appropriate for both toxicologic training and the scientific interest of our colleague.



Although the philosophy and design of this book evolved over a long period of friendship and mutual respect between the editors, the effort needed to convert ideas into reality was undertaken primarily by Louis J. Casarett. Thus, his death at a time when completion of the manuscript was in sight was particularly tragic. With the help and encouragement of his wife, Margaret G. Casarett, and the other contributors, we have finished Lou’s task. This volume is a fitting embodiment of Louis J. Casarett’s dedication to toxicology and to toxicologic education.



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