TY - CHAP M1 - Book, Section TI - The Nature of Bonding in Organic Molecules A1 - Renslo, Adam A1 - Koltun, Dmitry A2 - Renslo, Adam PY - 2016 T2 - The Organic Chemistry of Medicinal Agents AB - In this chapter, we will review fundamental concepts of chemical structure and bonding in the organic molecules that make up drugs and their biological targets. By “organic,” we mean molecules that are constructed primarily from the element carbon (C). Carbon exhibits striking versatility in its ability to form various different bonding arrangements with other carbon atoms as well as with other biologically relevant elements such as nitrogen (N), oxygen (O), sulfur (S), and phosphorus (P). It is this versatility that allowed carbon-based life to emerge on our planet. Thus, to understand the molecules of life—proteins, lipids, nucleic acids, hormones, etc.—and the drugs that interact with them, we must start with a solid understanding of structure and bonding in organic molecules. In this chapter, we will begin by contrasting the nature of ionic and covalent bonding and will describe the polarization of covalent bonds. We will then dive deeper into the nature of the covalent bond, discussing atomic and molecular orbitals, the “hybridization” of orbitals, and aromaticity. Finally, we will review some important functional groups and organic ring systems that figure prominently in the structures of biological molecules and drugs. SN - PB - McGraw-Hill Education CY - New York, NY Y2 - 2024/03/28 UR - accessbiomedicalscience.mhmedical.com/content.aspx?aid=1124842193 ER -