TY - CHAP M1 - Book, Section TI - Methods of Molecular Analysis A1 - Joshua, Anthony M. A1 - Boutros, Paul C. A1 - Kislinger, Thomas A2 - Tannock, Ian F. A2 - Hill, Richard P. A2 - Bristow, Robert G. A2 - Harrington, Lea PY - 2016 T2 - The Basic Science of Oncology, 5e AB - Advances made over the last 10 years in understanding the biology of cancer have transformed the field of oncology. While genetic analysis was limited previously to gross chromosomal abnormalities in karyotypes, DNA in cells can now be analyzed to the individual base pair level. This intricate knowledge of the genetics of cancer increases the possibility that personalized treatment for individual cancers lies in the near future. To appreciate the relevance and nature of these technological advances, as well as their implications for function, an understanding of the modern tools of molecular biology is essential. This chapter reviews the cytogenetic, nucleic, proteomic, and bioinformatics methods used to study the molecular basis of cancer, and highlights methods that are likely to affect in the future management of cancer. SN - PB - McGraw-Hill Education Medical CY - New York, NY Y2 - 2024/03/28 UR - accessbiomedicalscience.mhmedical.com/content.aspx?aid=1127471318 ER -