TY - CHAP M1 - Book, Section TI - Angiogenesis A1 - Rak, Janusz A2 - Tannock, Ian F. A2 - Hill, Richard P. A2 - Bristow, Robert G. A2 - Harrington, Lea PY - 2016 T2 - The Basic Science of Oncology, 5e AB - An important feature of malignancies is the associated emergence of new and abnormal contact points between cancer cells and the various facets of the host vascular system (Folkman and Kalluri, 2003; Kerbel, 2008). Prior to transformation many normal epithelial tissues (eg, in the gut, skin, and exocrine glands) are functionally linked to, but often anatomically separated from, the vasculature, for instance, by basement membranes and connective tissue layers (Rak, 2009). These barriers are compromised during the course of the malignant process, resulting in abnormal, often direct and reciprocal interactions between vascular components (endothelial cells, blood cells, plasma, or lymph) and cancer cells at this new tumor–vascular interface. SN - PB - McGraw-Hill Education Medical CY - New York, NY Y2 - 2024/03/28 UR - accessbiomedicalscience.mhmedical.com/content.aspx?aid=1127472458 ER -