TY - CHAP M1 - Book, Section TI - NORMAL HEMOSTASIS A1 - Hillman, Robert S. A1 - Ault, Kenneth A. A1 - Leporrier, Michel A1 - Rinder, Henry M. PY - 2016 T2 - Hematology in Clinical Practice, 5e AB - Normal hemostasis is best conceptualized according to its major components—vessel wall, platelet function, coagulation factor cascade, and clot inhibition/fibrinolysis. These components work together to prevent prolonged bleeding or thrombosis under normal physiologic conditions. Disruption of the vascular endothelium is a potent stimulus to clot formation. As a localized process, hemostasis by cellular and protein components acts to seal the break in vascular continuity, limit blood loss, and begin the process of wound healing. Prevention of an exuberant response that would result in pathologic thrombosis involves counterbalancing mechanisms, including anticoagulant properties of intact endothelial cells, circulating inhibitors of activated coagulation factors, and localized fibrinolytic enzymes. Most abnormalities in hemostasis involve a defect in 1 or more of the integrated steps in this coagulation process. It is important, therefore, to understand the physiology of hemostasis. SN - PB - McGraw-Hill Medical CY - New York, NY Y2 - 2024/03/29 UR - accessbiomedicalscience.mhmedical.com/content.aspx?aid=1127768032 ER -