TY - CHAP M1 - Book, Section TI - Diabetes Mellitus: Complications A1 - Powers, Alvin C. A2 - Jameson, J. Larry PY - 2017 T2 - Harrison's Endocrinology, 4e AB - Diabetes-related complications affect many organ systems and are responsible for the majority of morbidity and mortality associated with the disease. Strikingly, in the United States, diabetes is the leading cause of new blindness in adults, renal failure, and nontraumatic lower extremity amputation. Diabetes-related complications usually do not appear until the second decade of hyperglycemia. Because type 2 ­diabetes mellitus (DM) often has a long asymptomatic period of hyperglycemia before diagnosis, many individuals with type 2 DM have complications at the time of diagnosis. Fortunately, many of the diabetes-related complications can be prevented or delayed with early detection, aggressive glycemic control, and efforts to minimize the risks of complications. SN - PB - McGraw-Hill Education CY - New York, NY Y2 - 2024/04/19 UR - accessbiomedicalscience.mhmedical.com/content.aspx?aid=1141275806 ER -