TY - CHAP M1 - Book, Section TI - INFECTIONS IN TRANSPLANT RECIPIENTS A1 - Finberg, Robert W. A1 - Fingeroth, Joyce A2 - Kasper, Dennis L. A2 - Fauci, Anthony S. PY - 2017 T2 - Harrison's Infectious Diseases, 3e AB - This chapter considers aspects of infection unique to patients receiving transplanted tissue. The evaluation of infections in transplant recipients involves consideration of both the donor and the recipient of the transplanted cells or organ. Two central issues are of paramount importance: (1) infectious agents (particularly viruses, but also bacteria, fungi, and parasites) can be introduced into the recipient by the donor; and (2) treatment of the recipient with medicine to prevent rejection can suppress normal immune responses, greatly increasing susceptibility to infection. Thus, what might have been a latent or asymptomatic infection in an immunocompetent donor or in the recipient prior to therapy can become a life-threatening problem when the recipient becomes immunosuppressed. The pretransplantation evaluation of each patient should be guided by an analysis of both (1) what infections the recipient is currently harboring, since organisms that exist in a state of latency or dormancy before the procedure may cause fatal disease when the patient receives immunosuppressive treatment; and (2) what organisms are likely to be transmitted by the donor, particularly those to which the recipient may be naïve. SN - PB - McGraw-Hill Education CY - New York, NY Y2 - 2024/03/29 UR - accessbiomedicalscience.mhmedical.com/content.aspx?aid=1141405352 ER -