TY - CHAP M1 - Book, Section TI - ZIKA VIRUS INFECTION AND ZIKA-ASSOCIATED CONGENITAL ABNORMALITIES A1 - Morens, David M. A1 - Fauci, Anthony S. A2 - Kasper, Dennis L. A2 - Fauci, Anthony S. PY - 2017 T2 - Harrison's Infectious Diseases, 3e AB - Zika is a mosquito-borne virus that is closely related to the dengue viruses and within the same taxonomic family as yellow fever virus. Although the majority of human Zika virus infections are asymptomatic or so mild that they may go unrecognized, ~20% of infections result in dengue-like illnesses with fever, myalgia, and rash. Long an obscure virus of little human consequence, Zika has since 2013 spread pandemically and directionally around the globe from Southeast Asia to the South Pacific Islands; in 2015–2016, it spread to South and Central America and the Caribbean (Figure 108-1), including the U.S. Commonwealth of Puerto Rico and the Territory of the U.S. Virgin Islands (USVI). From these epidemics, travel-related cases and exported cases were observed in 2016 in all 50 U.S. states and the District of Columbia as well as in many other nations. Many primary care and other providers thus face diagnosing Zika cases and counseling patients about both actual Zika risks and unfounded fears. During this recent pandemic spread, Zika has been temporally and geographically linked in some countries to fetal development of microcephaly and other birth defects. In adults, Zika infection has been linked to Guillain-Barré syndrome and possibly to apparently rare cases of acute meningoencephalitis and myelitis. SN - PB - McGraw-Hill Education CY - New York, NY Y2 - 2024/10/09 UR - accessbiomedicalscience.mhmedical.com/content.aspx?aid=1141412427 ER -