TY - CHAP M1 - Book, Section TI - Modulation of Synaptic Transmission and Neuronal Excitability: Second Messengers A1 - Kandel, Eric R. A1 - Koester, John D. A1 - Mack, Sarah H. A1 - Siegelbaum, Steven A. PY - 2021 T2 - Principles of Neural Science, 6e AB - THE BINDING OF NEUROTRANSMITTER to postsynaptic receptors produces a postsynaptic potential either directly, by opening ion channels, or indirectly, by altering ion channel activity through changes in the postsynaptic cell’s biochemical state. As we saw in Chapters 11 to 13, the type of postsynaptic action depends on the type of receptor. Activation of an ionotropic receptor directly opens an ion channel that is part of the receptor macromolecule itself. In contrast, activation of metabotropic receptors regulates the opening of ion channels indirectly through biochemical signaling pathways; the metabotropic receptor and the ion channels regulated by the receptor are distinct macromolecules (Figure 14–1). SN - PB - McGraw Hill CY - New York, NY Y2 - 2024/12/04 UR - accessbiomedicalscience.mhmedical.com/content.aspx?aid=1180640844 ER -