TY - CHAP M1 - Book, Section TI - Differentiation and Survival of Nerve Cells A1 - Kandel, Eric R. A1 - Koester, John D. A1 - Mack, Sarah H. A1 - Siegelbaum, Steven A. PY - 2021 T2 - Principles of Neural Science, 6e AB - IN THE PRECEDING CHAPTER, WE DESCRIBED how local inductive signals pattern the neural tube and establish the early regional subdivisions of the nervous system—the spinal cord, hindbrain, midbrain, and forebrain. Here, we turn to the issue of how progenitor cells within these regions differentiate into neurons and glial cells, the two major cell types of the nervous system. The mature brain comprises billions of nerve cells and a similar number of glial cells arranged in complex patterns, yet its precursor, the neural plate, initially contains only a few hundred cells arranged in a simple columnar epithelium. From this observation alone, it should be apparent that the generation of neural cells and their delivery to appropriate sites must be carefully regulated. SN - PB - McGraw Hill CY - New York, NY Y2 - 2024/03/28 UR - accessbiomedicalscience.mhmedical.com/content.aspx?aid=1192998911 ER -