TY - CHAP M1 - Book, Section TI - Genetic Toxicology A1 - Preston, R. Julian A1 - Hoffmann, George R. PY - 2012 T2 - Casarett and Doull's Toxicology: The Basic Science of Poisons, 8e AB - What Is Genetic Toxicology?History of Genetic ToxicologyHealth Impact of Genetic AlterationsSomatic CellsGerm CellsCancer and Genetic Risk AssessmentsCancer Risk AssessmentGenetic Risk AssessmentMechanisms of Induction of Genetic AlterationsDNA DamageIonizing RadiationsUltraviolet LightChemicalsEndogenous AgentsDNA RepairBase Excision RepairNucleotide Excision RepairDouble-Strand Break RepairMismatch RepairO6-Methylguanine-DNA Methyltransferase RepairFormation of Gene MutationsSomatic CellsGerm CellsFormation of Chromosomal AlterationsSomatic CellsGerm CellsAssays for Detecting Genetic AlterationsIntroduction to Assay DesignStructural Alerts and In Silico AssaysDNA Damage and Repair AssaysGene Mutations in ProkaryotesGenetic Alterations in Nonmammalian EukaryotesGene Mutations and Chromosome AberrationsMitotic RecombinationGene Mutations in MammalsGene Mutations In VitroGene Mutations In VivoTransgenic AssaysMammalian Cytogenetic AssaysChromosome AberrationsMicronucleiSister Chromatid ExchangesAneuploidyGerm Cell MutagenesisGene MutationsChromosomal AlterationsDominant Lethal MutationsDevelopment of Testing StrategiesHuman Population MonitoringNew Approaches for Genetic ToxicologyAdvances in CytogeneticsMolecular Analysis of Mutations and Gene ExpressionConclusionsAcknowledgments SN - PB - McGraw-Hill Education CY - New York, NY Y2 - 2024/12/04 UR - accessbiomedicalscience.mhmedical.com/content.aspx?aid=1100086685 ER -