TY - CHAP M1 - Book, Section TI - Genetic Mechanisms in Degenerative Diseases of the Nervous System PY - 2014 T2 - Principles of Neural Science, Fifth Edition AB - Expanded Trinucleotide Repeats Characterize Several Neurodegenerative DiseasesHuntington Disease Involves Degeneration of the StriatumSpinobulbar Muscular Atrophy Is Due to Abnormal Function of the Androgen ReceptorHereditary Spinocerebellar Ataxias Include Several Diseases with Similar Symptoms but Distinct EtiologiesParkinson Disease Is a Common Degenerative Disorder of the ElderlySelective Neuronal Loss Occurs After Damage to Ubiquitously Expressed GenesAnimal Models Are Powerful Tools for Studying Neurodegenerative DiseasesMouse Models Reproduce Many Features of Neurodegenerative DiseasesInvertebrate Models Manifest Progressive NeurodegenerationSeveral Pathways Underlie the Pathogenesis of Neurodegenerative DiseasesProtein Misfolding and Degradation Contribute to Parkinson DiseaseProtein Misfolding Triggers Pathological Alterations in Gene ExpressionMitochondrial Dysfunction Exacerbates Neurodegenerative DiseaseApoptosis and Caspase Modify the Severity of NeurodegenerationAdvances in Understanding the Molecular Basis of Neurodegenerative Diseases Are Opening Possibilities for Approaches to Therapeutic InterventionAn Overall View SN - PB - McGraw-Hill Education CY - New York, NY Y2 - 2024/03/28 UR - accessbiomedicalscience.mhmedical.com/content.aspx?aid=1101682192 ER -