TY - CHAP M1 - Book, Section TI - Coronary Artery Disease A1 - Ahmad, Tariq A1 - Ridker, Paul M. A2 - Murray, Michael F. A2 - Babyatsky, Mark W. A2 - Giovanni, Monica A. A2 - Alkuraya, Fowzan S. A2 - Stewart, Douglas R. PY - 2014 T2 - Clinical Genomics: Practical Applications in Adult Patient Care AB - Disease summary:Coronary artery disease (CAD) is a multifactorial disorder that results from interplay between genetic and environmental factors.CAD is the most common cause of death worldwide.CAD is a progressive disease process that generally begins in childhood and manifests clinically in mid-to-late adulthood. It results from the accumulation of atherosclerotic changes within the walls of coronary arteries. The distribution of lipid and connective tissue, and the degree of inflammation in the atherosclerotic lesions determine whether they are stable or at risk of rupture, and subsequent thrombosis, causing acute coronary syndromes (ACSs).Hypertension, hypercholesterolemia, smoking, and diabetes are major risk factors for CAD. However, they do not account for up to 15% to 20% of patients with myocardial infarction (MI); such patients often have a family history of CAD, pointing to an integral role of genetics in the development of this disease.Commonly used CAD risk prediction models such as the Framingham risk score take into account known risk factors such as age, plasma lipid levels, blood pressure, tobacco use, and type 2 diabetes. Newer models such as the Reynolds risk score additionally include family history as an independent risk factor but the exact mechanisms by which risk of CAD is inherited remain unclear. SN - PB - McGraw-Hill Education CY - New York, NY Y2 - 2024/03/28 UR - accessbiomedicalscience.mhmedical.com/content.aspx?aid=1102698736 ER -