TY - CHAP M1 - Book, Section TI - Thrombophilia A1 - L. Kujovich, Jody A2 - Murray, Michael F. A2 - Babyatsky, Mark W. A2 - Giovanni, Monica A. A2 - Alkuraya, Fowzan S. A2 - Stewart, Douglas R. PY - 2014 T2 - Clinical Genomics: Practical Applications in Adult Patient Care AB - Disease summary:The term thrombophilia refers to an inherited or acquired predisposition to thromboembolism.Inherited thrombophilias include deficiencies of the three natural anticoagulant proteins antithrombin (AT), protein C (PC), and protein S (PS), and specific mutations in the genes for factor V (factor V Leiden) and prothrombin (prothrombin 20210G>A).Inherited thrombophilias increase the risk for a first venous thromboembolism (VTE) 2- to 20-fold but are not major risk factors for arterial thromboembolism.Although the risks vary, inherited thrombophilias are not strongly predictive of recurrent VTE after an initial episode.The clinical expression of an inherited thrombophilia reflects a complex interplay between genetic and acquired risk factors. SN - PB - McGraw-Hill Education CY - New York, NY Y2 - 2024/03/28 UR - accessbiomedicalscience.mhmedical.com/content.aspx?aid=1102699126 ER -