TY - CHAP M1 - Book, Section TI - Hereditary Pheochromocytoma and Paraganglioma A1 - Giovanni, Monica A. A1 - Annes, Justin P. A2 - Murray, Michael F. A2 - Babyatsky, Mark W. A2 - Giovanni, Monica A. A2 - Alkuraya, Fowzan S. A2 - Stewart, Douglas R. PY - 2014 T2 - Clinical Genomics: Practical Applications in Adult Patient Care AB - Disease summary:Paraganglia are clusters of neuroendocrine cells that comprise the sympathetic ganglia, the parasympathetic ganglia, and the adrenal medulla. A paraganglioma (PGL) is a tumor that derives from paraganglia.The term pheochromocytoma (PHEO) is applied to catecholamine-secreting paragangliomas of the adrenal gland.Extra-adrenal paragangliomas (ePGLs) may be categorized as either sympathetic (usually found in the abdomen) or parasympathetic (usually found in the head and neck; hnPGL) paragangliomas.PHEOs and ePGLs most commonly present with hypertension, headache, anxiety, and/or palpitations.hnPGLs usually present as an enlarging mass or with a mass effect such as a cranial nerve palsy (eg, Horner syndrome).PGLs have an estimated prevalence of 1 in 5000 and an estimated incidence of 1 in 30,000. SN - PB - McGraw-Hill Education CY - New York, NY Y2 - 2024/03/28 UR - accessbiomedicalscience.mhmedical.com/content.aspx?aid=1102700751 ER -