TY - CHAP M1 - Book, Section TI - Natural Products in Cancer Chemotherapy: Hormones and Related Agents A1 - Hilal-Dandan, Randa A1 - Brunton, Laurence L. Y1 - 2016 N1 - T2 - Goodman and Gilman's Manual of Pharmacology and Therapeutics, 2e AB - The growth of a number of cancers is hormone-dependent or regulated by hormones. Glucocorticoids are used for their antiproliferative and lympholytic properties and to ameliorate untoward responses to other treatments. Estrogen, androgen, and GnRH analogs and antagonists are effective in extending survival and delaying or preventing tumor recurrence of both breast and prostate cancer. These molecules interrupt the stimulatory axis created by systemic pools of androgens and estrogens, inhibit hormone production or hormone binding to receptors, and ultimately block expression of genes that promote tumor growth and survival. SN - PB - McGraw-Hill Education CY - New York, NY Y2 - 2024/03/28 UR - accessbiomedicalscience.mhmedical.com/content.aspx?aid=1127555064 ER -