TY - CHAP M1 - Book, Section TI - ANTIVIRAL CHEMOTHERAPY, EXCLUDING ANTIRETROVIRAL DRUGS A1 - Baden, Lindsey R. A1 - Dolin, Raphael A2 - Kasper, Dennis L. A2 - Fauci, Anthony S. Y1 - 2017 N1 - T2 - Harrison's Infectious Diseases, 3e AB - The field of antiviral therapy—both the number of antiviral drugs and our understanding of their optimal use—historically has lagged behind that of antibacterial treatment, but significant progress has been made in recent years on new drugs for several viral infections. The development of antiviral drugs poses several challenges. Viruses replicate intracellularly and often use host cell enzymes, macromolecules, and organelles for synthesis of viral particles. Therefore, useful antiviral compounds must discriminate between host and viral functions with a high degree of specificity; agents without such selectivity are likely to be too toxic for clinical use. SN - PB - McGraw-Hill Education CY - New York, NY Y2 - 2024/10/04 UR - accessbiomedicalscience.mhmedical.com/content.aspx?aid=1141410603 ER -