TY - CHAP M1 - Book, Section TI - HUMAN PAPILLOMAVIRUS INFECTIONS A1 - Ermel, Aaron C. A1 - Brown, Darron R. A2 - Kasper, Dennis L. A2 - Fauci, Anthony S. Y1 - 2017 N1 - T2 - Harrison's Infectious Diseases, 3e AB - Investigation of human papillomavirus (HPV) infection began in earnest in the 1980s after Harold zur Hausen postulated that infection with these viruses was associated with cervical cancer. It is now recognized that HPV infection of the human genital tract is extremely common and causes clinical states ranging from asymptomatic infection to genital warts (condylomata acuminata); dysplastic lesions or invasive cancers of the anus, penis, vulva, vagina, and cervix; and a subset of oropharyngeal cancers. This chapter describes the epidemiology of HPV in general and as a pathogen, the natural history of HPV infections and associated cancers, strategies to prevent HPV infection and HPV-associated disease, and treatment modalities. SN - PB - McGraw-Hill Education CY - New York, NY Y2 - 2024/10/04 UR - accessbiomedicalscience.mhmedical.com/content.aspx?aid=1141410968 ER -