TY - CHAP M1 - Book, Section TI - Chemical Carcinogenesis A1 - Klaunig, James E. A1 - Wang, Zemin A2 - Klaassen, Curtis D. Y1 - 2019 N1 - T2 - Casarett & Doull’s Toxicology: The Basic Science of Poisons, 9th edition AB - Cancer is a disease characterized by genomic mutation, modified gene expression, cell proliferation, and aberrant cell growth. It ranks as one of the leading causes of death in the world. In the United States, cancer ranks as the second leading cause of death, with over 1.68 million new cases of cancer diagnosed and more than 0.6 million Americans dying from cancer annually (Siegel et al., 2016). Multiple causes of cancer have been established including infectious agents, radiation, and chemicals. Estimates suggest that 70% to 90% of all human cancers have a linkage to environmental, dietary, and behavioral factors (Fig. 8-1). Although our understanding of the biology of the progression from a normal cell to a malignant one has advanced considerably in the past several decades, many aspects of the cause, prevention, and treatment of human cancer and in particular the influence of lifestyle remain to be completely resolved. SN - PB - McGraw-Hill Education CY - New York, NY Y2 - 2024/11/02 UR - accessbiomedicalscience.mhmedical.com/content.aspx?aid=1158497752 ER -