TY - CHAP M1 - Book, Section TI - Cellular Signaling A1 - Harrington, Lea A. A2 - Harrington, Lea A. A2 - Tannock, Ian F. A2 - Hill, Richard P. A2 - Cescon, David W. Y1 - 2021 N1 - T2 - The Basic Science of Oncology, 6e AB - The perturbation and conscription of normal cellular signaling processes is one of the defining features in the development of cancer (Hanahan and Weinberg, 2011). A major challenge in the development of therapeutics against signaling networks is the ability to target these perturbations without interfering with the ability of normal cells and tissues to receive and respond to extracellular signals. The ability to respond to extracellular signals is essential to our ability to respond to our physical or chemical environment, and to initiate the necessary modifications of cell metabolism, morphology, movement, and proliferation. These responses are brought about by elaborate networks of intracellular signals transmitted by changes in protein phosphorylation and enzymatic activity, localization, and the formation of protein-protein complexes. In turn, cellular responses are triggered by the recognition of extracellular signals at the cell surface, resulting in the activation of cytoplasmic enzymes that trigger biochemical cascades in the cytoplasm and nucleus. These signal transduction networks are critical to numerous cellular processes that range from the generalized control of cell proliferation and survival, to specialized functions such as the immune response and angiogenesis. This chapter will focus on how the dysregulation of networks involved in normal growth, adhesion, and development contribute to malignant transformation in human cells, and how these perturbations can be exploited to develop new cancer therapeutics. SN - PB - McGraw-Hill Education CY - New York, NY Y2 - 2024/03/29 UR - accessbiomedicalscience.mhmedical.com/content.aspx?aid=1179323755 ER -