TY - CHAP M1 - Book, Section TI - Toxic Responses of the Respiratory System A1 - Leikauf, George D. A2 - Klaassen, Curtis D. A2 - Watkins III, John B. Y1 - 2015 N1 - T2 - Casarett & Doull’s Essentials of Toxicology, 3e AB - Inhaled xenobiotics can affect lung tissues directly or distant organs after absorption.Water solubility is a decisive factor in determining how deeply a given gas penetrates into the lung.Particle size is usually the critical factor that determines the region of the respiratory tract in which a particle or an aerosol will deposit.The lung contains most of the enzymes involved in xenobiotic biotransformation that have been identified in other tissues.Asthma is characterized by increased reactivity of the bronchial smooth muscle in response to exposure to irritants.In emphysema, destruction of the gas-exchanging surface area results in a distended, hyperinflated lung that no longer effectively exchanges oxygen and carbon dioxide. SN - PB - McGraw-Hill Education CY - New York, NY Y2 - 2024/03/29 UR - accessbiomedicalscience.mhmedical.com/content.aspx?aid=1113950441 ER -