TY - CHAP M1 - Book, Section TI - Nanotoxicology A1 - Oberdörster, Gunter A1 - Kane, Agnes B. A1 - Kapler, Rebecca D. A1 - Hurt, Robert H. A2 - Klaassen, Curtis D. A2 - Watkins III, John B. Y1 - 2015 N1 - T2 - Casarett & Doull’s Essentials of Toxicology, 3e AB - Nanotechnology is the understanding and control of matter at nanoscale dimensions between approximately 1 and 100 nm, where unique phenomena enable novel applications.Nanotoxicology can be defined as the study of adverse effects of nanomaterials on living organisms and the environment.Surface properties are major determinants of biologic reactivity due to high surface area, surface charge, dissolution and release of metal ions, and redox activity leading to generation of ROS.The respiratory tract is the major route for humans to exposure of nanomaterials.Surface properties are major determinants of biologic reactivity due to high surface area, surface charge, hydrophobicity and partitioning into lipid membranes, dissolution and release of metal ions, and redox activity.Dosemetric defines a dose in terms of an inherent property (physical, chemical, reactivity, etc.). SN - PB - McGraw-Hill Education CY - New York, NY Y2 - 2024/03/29 UR - accessbiomedicalscience.mhmedical.com/content.aspx?aid=1113952235 ER -