TY - CHAP M1 - Book, Section TI - Blood Coagulation and Anticoagulant, Fibrinolytic, and Antiplatelet Drugs A1 - Weitz, Jeffrey I. A2 - Brunton, Laurence L. A2 - Chabner, Bruce A. A2 - Knollmann, Björn C. PY - 2015 T2 - Goodman & Gilman's: The Pharmacological Basis of Therapeutics, 12e AB - The physiological systems that control the fluidity of blood are both complex and elegant. Blood must remain fluid within the vasculature and yet clot quickly when exposed to subendothelial surfaces at sites of vascular injury. When intravascular thrombi form, rapid activation of the fibrinolytic system restores fluidity. Under normal circumstances, a delicate balance between coagulation and fibrinolysis prevents both thrombosis and hemorrhages. Alteration of this balance in favor of coagulation results in thrombosis. SN - PB - McGraw-Hill Education CY - New York, NY Y2 - 2023/05/31 UR - accessbiomedicalscience.mhmedical.com/content.aspx?aid=1127868083 ER -