TY - CHAP M1 - Book, Section TI - Estrogens and Progestins A1 - Hilal-Dandan, Randa A1 - Brunton, Laurence L. PY - 2016 T2 - Goodman and Gilman's Manual of Pharmacology and Therapeutics, 2e AB - Estrogens and progestins are hormones that produce myriad physiological actions. In women, these include developmental effects, neuroendocrine actions involved in the control of ovulation, the cyclical preparation of the reproductive tract for fertilization and implantation, and major actions on mineral, carbohydrate, protein, and lipid metabolism. Estrogens also have important actions in males, including effects on bone, spermatogenesis, and behavior. The most common uses of these agents are menopausal hormone therapy and contraception in women, but the specific compounds and dosages used in these 2 settings differ substantially. Anti-estrogens are used in the treatment of hormone-responsive breast cancer and infertility. Selective estrogen receptor modulators (SERMs) that display tissue-selective agonist or antagonist activities are useful to prevent breast cancer and osteoporosis. The main use of antiprogestins has been for medical abortion. SN - PB - McGraw-Hill Education CY - New York, NY Y2 - 2024/12/04 UR - accessbiomedicalscience.mhmedical.com/content.aspx?aid=1127552135 ER -