TY - CHAP M1 - Book, Section TI - Chemotherapy of Protozoal Infections: Amebiasis, Giardiasis, Trichomoniasis, Trypanosomiasis, Leishmaniasis, and Other Protozoal Infections A1 - Hilal-Dandan, Randa A1 - Brunton, Laurence L. PY - 2016 T2 - Goodman and Gilman's Manual of Pharmacology and Therapeutics, 2e AB - Humans host a wide variety of protozoal parasites that can be transmitted by insect vectors, directly from other mammalian reservoirs or from one person to another. The immune system plays a crucial role in protecting against the pathological consequences of protozoal infections. Thus, opportunistic infections with protozoa are prominent in infants, individuals with cancer, transplant recipients, those receiving immunosuppressive drugs or extensive antibiotic therapy, and persons with advanced human immunodeficiency virus (HIV) infection. Because effective vaccines are unavailable, chemotherapy has been the only practical way to both treat infected individuals and reduce transmission. Many effective antiprotozoal drugs are toxic at therapeutic doses, a problem exacerbated by increasing drug resistance. SN - PB - McGraw-Hill Education CY - New York, NY Y2 - 2024/10/09 UR - accessbiomedicalscience.mhmedical.com/content.aspx?aid=1127553273 ER -