TY  - CHAP
M1  - Book, Section
TI  - MOLECULAR MECHANISMS OF MICROBIAL PATHOGENESIS
A1  - Pier, Gerald B.
A2  - Kasper, Dennis L.
A2  - Fauci, Anthony S.
PY  - 2017
T2  - Harrison's Infectious Diseases, 3e
AB  - Over  the  past  four  decades,  molecular  studies  of  the  pathogenesis  of  microorganisms  have  yielded  an  explosion  of  information  about  the  various  microbial  and  host  molecules  that  contribute  to  the  processes  of  infection  and  disease.  These  processes  can  be  classified  into  several  stages:  microbial  encounter  with  and  entry  into  the  host;  microbial  growth  after  entry;  avoidance  of  innate  host  defenses;  tissue  invasion  and  tropism;  tissue  damage;  and  transmission  to  new  hosts.  Virulence  is  the  measure  of  an  organism’s  capacity  to  cause  disease  and  is  a  function  of  the  pathogenic  factors  elaborated  by  microbes.  These  factors  promote  colonization  (the  simple  presence  of  potentially  pathogenic  microbes  in  or  on  a  host),  infection  (attachment  and  growth  of  pathogens  and  avoidance  of  host  defenses),  and  disease  (often,  but  not  always,  the  result  of  activities  of  secreted  toxins  or  toxic  metabolites).  In  addition,  the  host’s  inflammatory  response  to  infection  greatly  contributes  to  disease  and  its  attendant  clinical  signs  and  symptoms.  The  recent  surge  of  interest  in  the  role  of  the  microbiota  and  its  associated  microbiome—the  collection  of  microbial  genomes  residing  in  or  on  mammalian  organisms—in  the  physiology  of,  susceptibility  to,  and  response  to  infection  and  in  immune  system  development  has  had  an  enormous  impact  on  our  understanding  of  host-pathogen  interaction.  
SN  - 
PB  - McGraw-Hill Education
CY  - New York, NY
Y2  - 2024/04/18
UR  - accessbiomedicalscience.mhmedical.com/content.aspx?aid=1141404324
ER  -