TY - CHAP M1 - Book, Section TI - Toxic Responses of the Skin A1 - Belsito, Donald V. A2 - Klaassen, Curtis D. A2 - Watkins, John B. PY - 2021 T2 - Casarett & Doull’s Essentials of Toxicology, 4e AB - KEY POINTSSkin participates directly in thermal, electrolyte, hormonal, metabolic, and immune regulation.Percutaneous absorption depends on the xenobiotic’s hydrophobicity, which affects its ability to partition into epidermal lipid, and rate of diffusion through this barrier.Cells of the epidermis and pilosebaceous units express biotransformation enzymes.Irritant dermatitis is a nonimmune-related response caused by the direct action of a chemical on the skin.Allergic contact dermatitis represents a delayed (type IV) hypersensitivity reaction, whereby minute quantities of material elicit overt reactions. SN - PB - McGraw Hill CY - New York, NY Y2 - 2024/03/28 UR - accessbiomedicalscience.mhmedical.com/content.aspx?aid=1178015655 ER -