TY - CHAP M1 - Book, Section TI - Directly Gated Transmission: The Nerve-Muscle Synapse A1 - Kandel, Eric R. A1 - Koester, John D. A1 - Mack, Sarah H. A1 - Siegelbaum, Steven A. PY - 2021 T2 - Principles of Neural Science, 6e AB - MUCH OF OUR UNDERSTANDING of the principles that govern chemical synapses in the brain is based on studies of synapses formed by motor neurons on skeletal muscle cells. The landmark work of Bernard Katz and his colleagues over three decades beginning in 1950 defined the basic parameters of synaptic transmission and opened the door to modern molecular analyses of synaptic function. Therefore, before we examine the complexities of synapses in the central nervous system, we will examine the basic features of chemical synaptic transmission at the simpler nerve-muscle synapse. SN - PB - McGraw Hill CY - New York, NY Y2 - 2024/03/29 UR - accessbiomedicalscience.mhmedical.com/content.aspx?aid=1180640602 ER -