TY - CHAP M1 - Book, Section TI - Seizures and Epilepsy A1 - Kandel, Eric R. A1 - Koester, John D. A1 - Mack, Sarah H. A1 - Siegelbaum, Steven A. PY - 2021 T2 - Principles of Neural Science, 6e AB - UNTIL QUITE RECENTLY, THE FUNCTION and organization of the human cerebral cortex—the region of the brain concerned with perceptual, motor, and cognitive functions—has eluded both clinicians and neuroscientists. In the past, the analysis of brain function relied largely on observations of loss of brain functions resulting from brain damage and cell loss caused by strokes or trauma. These natural experiments provided much of the early evidence that distinct brain regions serve specific functions, or as the famous American neurologist C. Miller Fisher said, “We learn about the brain ‘stroke by stroke.’” Observation of patients with seizures and epilepsy has been equally important in the study of brain function because the behavioral consequences of these disorders of neural hyperactivity inform clinicians how activation affects the brain regions from which they originate. SN - PB - McGraw Hill CY - New York, NY Y2 - 2022/08/08 UR - accessbiomedicalscience.mhmedical.com/content.aspx?aid=1180646585 ER -